All human beings today belong to the Homo sapiens species, and it is widely accepted amongst researchers, historians, and scientists, that all of human history began on the continent of Africa. The exact location in Africa is a topic of constant debate as remains have been found in various locations throughout the continent, such as Ethiopia, Kenya, and Morocco, though researchers suggest it was most likely in the Horn of Africa. The oldest known remains of our species to date has been found in Jebel Irhoud, Morocco and dated about 315,000 years ago.

Early modern humans expanded to Western Eurasia and Central, Western and Southern Africa from the time of their emergence. Evidence of migration out of Africa, via a partial skull, was discovered in the Apidima Cave in southern Greece and is dated more than 210,000 years old. There were several waves of migrations, many via northern Africa and the Arabian Peninsula about 130,000 YA (Years Ago), though most of these early waves appear to have mostly died out or retreated by 80,000 YA.

Mitochondrial Eve (the name alludes to the biblical Eve) is the matrilineal most recent common ancestor of all living humans. In other words, she is defined as the most recent woman from whom all living humans descend in an unbroken line purely through their mothers and through the mothers of those mothers, back until all lines converge on one woman. In 1987, geneticists compared the mitochondrial DNA (genetic information passed from mothers to their offspring) of people from different populations around the world and find that they all link in an unbroken line to Mitochondrial Eve. This does not mean that she was the first woman, nor the only living female of her time, nor the first member of a "new species." It only means that she is the most recent female ancestor to which all living humans are linked. She was believed to have lived in either East Africa or Botswana.

The earliest Egyptians were indigenous Africans who were drawn to the Sahara when it was a humid region rich in grasslands and with plentiful water. There was a widespread Saharan Neolithic culture. However, during this same period (c. 10,000 - c. 6,000 BC), the Earth's axis tilted, causing the Saharan climate to slowly transform from humid to arid, prompting Saharan Africans to migrate to the Nile Valley to take advantage of its fertile floodplains.